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Table 1 Synonymous (Ks) and non-synonymous (Ka) substitution rates for the human-mouse-rat orthologous protein sets

From: Constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins

  All Selected P §
Human versus rodent*
Ks 0.496 ± 0.14 0.692 ± 0.19 4.5 × 10-3
Ka 0.079 ± 0.08 0.349 ± 0.08 2.4 × 10-7
Ka/Ks 0.147 ± 0.13 0.537 ± 0.18 1.3 × 10-5
Mouse versus rat
Ks 0.172 ± 0.06 0.193 ± 0.07 0.57
Ka 0.029 ± 0.03 0.148 ± 0.04 5.7 × 10-3
Ka/Ks 0.161 ± 0.16 0.787 ± 0.12 2.0 × 10-3
  1. *Average Ks and Ka for the human-mouse and human-rat pairwise comparisons. Average and standard deviation values for all protein sets. Average and standard deviation values for the protein sets identified as having accelerated rates of amino-acid substitution. §P value associated with a t-test comparing the means of the all versus selected protein sets. Average Ks and Ka for the mouse-rat pairwise comparisons.