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Table 1 Synonymous (Ks) and non-synonymous (Ka) substitution rates for the human-mouse-rat orthologous protein sets

From: Constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins

 

All†

Selected‡

P §

Human versus rodent*

Ks

0.496 ± 0.14

0.692 ± 0.19

4.5 × 10-3

Ka

0.079 ± 0.08

0.349 ± 0.08

2.4 × 10-7

Ka/Ks

0.147 ± 0.13

0.537 ± 0.18

1.3 × 10-5

Mouse versus rat¶

Ks

0.172 ± 0.06

0.193 ± 0.07

0.57

Ka

0.029 ± 0.03

0.148 ± 0.04

5.7 × 10-3

Ka/Ks

0.161 ± 0.16

0.787 ± 0.12

2.0 × 10-3

  1. *Average Ks and Ka for the human-mouse and human-rat pairwise comparisons. †Average and standard deviation values for all protein sets. ‡Average and standard deviation values for the protein sets identified as having accelerated rates of amino-acid substitution. §P value associated with a t-test comparing the means of the all versus selected protein sets. ¶ Average Ks and Ka for the mouse-rat pairwise comparisons.