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Figure 2 | Genome Biology

Figure 2

From: What use is the human genome for understanding the mouse?

Figure 2

Building mouse clone contigs using a human scaffold. The solid black bar at the top of the diagram represents human genomic sequence, and the smaller clusters of horizontal lines are two fingerprinted mouse BAC contigs, a and b. Dashes at the ends of some of the BACs represent insert-end sequences. The vertical arrows indicate significant sequence homologies (detected using BLAST) between human genomic sequence and mouse BAC end sequence. These homologies are then used to anchor, orient and order the mouse BAC contigs relative to the human sequence. In some cases, the alignment of two or more contigs with the human sequence allows identification of BAC clone overlaps missed in the original contig building, so that contigs can be merged together.

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