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Figure 5 | Genome Biology

Figure 5

From: Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

Figure 5

Subgrouping of induced genes of PBMCs. Purified PBMCs were induced with PI for 1, 3, 6 or 24 h before harvesting for microarray analysis. The induced samples were labeled red (Cy5) and uninduced samples were labeled green (Cy3). For analyzing the turnover rate of these induced transcripts, purified PBMCs were first induced with PI treatment for 3 h followed by flavopiridol treatment for 1, 2, 4 or 6 h before harvesting for microarray analysis. The induced samples treated with flavopiridol were labeled red (Cy5) and induced samples without flavopiridol treatment were labeled green (Cy3). (a) Percentages of genes (induced or not induced by PI) are plotted according to their half-lives (indicated by the different colors). (b) Percentages of genes of certain functional groups (induced or not induced by PI) are plotted according to their half-lives. (c) Microarray data showing highly induced genes with short half-lives of certain functional groups. (d) Microarray data showing half-lives of highly induced chemokines, cytokines and their receptors.

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