The nitrilase superfamily: classification, structure and function

Table 1 Summary of the enzyme activities of the nitrilase superfamily

Nitrilase branch	Nitrilase	Amidase		Reverse amidase	Carbamylase	Protein substrate
	R-CN
1 - Nitrilase	Yes
2 - Aliphatic amidase		Yes
3 - Amino-terminal amidase		Yes				Yes
4 - Biotinidase		Yes	Yes			Sometimes
5 -β-Ureidopropionase		Yes			Yes
6 - Carbamylase Yes					Yes
7 - Prokaryote NAD synthetase		Predicted
8 - Eukaryote NAD synthetase		Predicted
9 - Apolipoprotein N-acyltransferase			Yes	Yes		Yes
10 -Nit and Nitfhit
11 -NB11
12 -NB12						Predicted
13 -Nonfused outliers

ISSN: 1474-760X