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Table 2 F-box proteins that function in SCF complexes

From: The F-box protein family

F-box protein Organism Substrates Mutant phenotype
Cdc4 S. cerevisiae Sic1 and Far1 - CDK inhibitors G1 cell-cycle arrest
   Cdc6 - DNA replication factor  
   Gcn4 - transcription factor  
Met30 S. cerevisiae Met4 - transcription factor G1 cell-cycle arrest
   Swe1 - cell cycle kinase  
Grr1 S. cerevisiae Cln1 and Cln2 - G1 cyclins Defective glucose signaling
   Gic2 - cytoskeleton regulator  
Pop1 S. pombe Rum1 - CDK inhibitor Polyploidy
   Cdc18 - DNA replication factor  
Pop2/Sud1 S. pombe Rum1 - CDK inhibitor Polyploidy
   Cdc18 - DNA replication factor  
Scon2* N. crassa ? Defective sulfur response
SconB* A. nidulans ? Defective sulfur response
TIR1 A. thaliana ? Defective auxin response
COI1* A. thaliana ? Defective jasmonite response
LIN-23* C. elegans ? Hyperplasia
SEL-10* C. elegans LIN-12 - cell surface receptor Basically wild type
Slimb* D. melanogaster Armadillo - adhesion and signaling Centrosome over-replication and mutant clones induce
   Cubitus Interruptus - transcription factor ectopic limbs in surrounding tissue
ß-TrCP H. sapiens ß-catenin - adhesion and signaling  
   I?Ba - transcription inhibitor ?
   CD4 - cell surface receptor (when cells are infected by HIV)  
ß-TrCP2/HOS H. sapiens ß-catenin - adhesion and signaling ?
   I?Ba - transcription inhibitor  
SKP2 H. sapiens / cyclin E- G1 cyclin (free, not bound by CDK2) Small mice with some polyploid tissues and centrosome
  M. musculus p27KIP1 - CDK inhibitor over-replication
  1. *F-box proteins that have not been experimentally demonstrated to function in SCF complexes, but each are orthologs of known SCF proteins in other organisms and so are likely to function in SCF complexes. Two other plant F-box proteins, UFO and FIM, are required for flower development in Arabidopsis thaliana and Antirrhinum majus, respectively [32,33]. Although both of these F-box proteins bind to Skp1 proteins, it is unclear whether they function in SCF complexes or bind Skp1 for other purposes, as is the case for Ctf13. Additional potential substrates that have not been conclusively documented are not listed. References can be obtained from [10], with the exception of the more recent references for LIN-23 [34], centrosome over-replication in Slimb mutants [35], and the substrates Met4 [36], Gcn4 [37], cyclin E [38], and p27KIP1 [25,38,39,40]. Species included in the table are Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora crassa, Aspergillus nidulans, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens and Mus musculus.