The F-box protein family

Table 1 F-box proteins in the yeast, nematode, and human genomes

Additional motifs	S. cerevisiae	C. elegans	Human
WD repeats	2	3	5
	Cdc4	LIN-23	FBXW1 (ß-TrCP)
	Met30	SEL-10	FBXW1B (ß-TrCP2/HOS)
		T01E8.4	FBXW2
			FBXW3
			FBXW6^*
Leucine-rich	2	3	10
repeats	Grr1	C02F5.7	FBXL1 (SKP2)
	YOR080w	F48E8.7	FBXL2
		F58E1.8	FBXL3A
			FBXL3B
			FBXL4 - FBXL7
			FBXL9
			FBXL11
FTH / DUF38	0	135 ^†	0
PfamB 45	0	56 ^†	0
Other/none	7	129 ^†	21
	El1a		FBXO1 (cyclin F)
	YNL311c		FBXO2 (NFB42)
	YML088w		FBXO3 - FBXO12^*
	YLR368w		FBXO20 - FBXO26^*
	YDR219c		FBXO29
	YJL149w		Elongin A
	YDR131c
Total	11	326	36

The proteins in this table were obtained from the European Bioinformatics Institute InterPro Project [29] with additional entries (20 for C. elegans and 3 for humans) discovered through database analysis by ETK. ^*This is the first report of FBXW6, FBXO12, and FBXO26 as F-box proteins. They were identified by database search and correspond to the GenBank [31] entries FLJ11071 (accession number NM_018315.1), FLJ20188 (accession number NM_017703), and KIAA1195/muscle disease-related protein (accession number AB033021/AF204674), respectively. FBXO12 is the apparent ortholog of murine fbxo12. Missing numbers in the human FBX gene series have been given to mouse genes for which the human orthologs have not (yet) been identified. ^†The very large number of C. elegans proteins in these categories are listed in Additional data file 1.

ISSN: 1474-760X