Table 7 A. pernix proteins conserved in a wide range of organisms but missing in euryarchaea (examples)

APE1618/1048

- - - - -zyq-d-ebr- - - - - - - - - -x

Aconitase A

Unlike other archaea with sequenced genomes, A. pernix is an aerobe and possesses the complete TCA cycle. APE1618 belongs to a distinct family of (otherwise) bacterial aconitases (e.g E. coli AcnA and B. subtilis CitB). APE1816 also belongs to a specific family of bacterial fumarases.

APE1816/0114

- - - - -zy- -dcebrhu- - - - - -i-x

Fumarase

APE1677/1071

- - - - -zy- -dc-br- - - -gp- -i-x

pyruvate dehydrogenase E1 component, a-subunit

APE1674/0022

- - - - -zy- -dc-br- - - -gp- -i-x

pyruvate dehydrogenase E1 component, ß-subunit

APE1671/0508

- - - - -zy- -dcebrh- - -gp- -i-x

Dihydrolipoamide acyltransferase

APE1725/1290

- - - - -z-q-dc-br-uj- - - - - -nx

Cytochrome b

As an aerobe, A. pernix encodes specific electron-transport chain components. APE1623 is closely related to the ortholog from Aquifex aeolicus.

APE1623, APE0793_1/0843

- - - - -z-q-dcebr-uj- - - - - -nx

Cytochrome c oxidase, heme b and copper-binding subunit

APE0793_2/

- - - - -z-q-dcebr- - - - - - - - - -x

Cytochrome oxidase, subunit 3

1845

APE1498/1171

- - - - -zy-vdcebrh- - - - - - - - -x

Threonine dehydratase

Specifically related to a subfamily of bacterial catabolic threonine dehydratases (e.g. E. coli TdcB)

APE1038/0295

- - - - -zy-vd-ebrh- -wgpo- - - -

Cytidine deaminase

APE1353/0514

- - - - -zy-dceb-h- - - - - -l- - -

DNA helicase (RecQ family)

APE1353 differs from other members of the RecQ family by the presence of long amino-terminal extension that probably form a non-globular domain. APE1353 shows no specific affinity to any of the bacterial orthologs.

APE2450/0260

- - - - -z-q-dcebrhu-wgp- -i-x

Leucyl aminopeptidase

APE0137/0405

- - - - -zy- -dcebr-u- - - - - - - - -

Gamma-glutamyltranspeptidase

APE2464/

- - - - -z-qvdcebr- - - - - - - - - - -

Phosphate starvation-inducible protein

COG1702

PhoH, Predicted ATPase

APE0993/>0813

- - - - -z- - -d-eb-hu-wgp-l- - -

Purine-nucleoside phosphorylase

Correlates with the absence of de novo purine biosynthesis and the probable importance of salvage pathways

APE2105/0813a

- - - - -z- - - - - -e- -h- - - - -l- - -

Uridine phosphorylase

APE0033/1866

- - - - -zy- -d-eb-h- - - - - - - - - -

Phosphoenolpyruvate carboxykinase