Host-pathogen studies in the post-genomic era

Table 2 Host and pathogen DNA array studies

Cell type	Pathogen	Array	Genes	Array type and support	Experiment	Reference
Human foreskin fibroblasts	Human cytomegalovirus	Pathogen	207 genes	Oligonucleotides on glass slides	Virus gene expression during lytic replication	[5]
Human B-cell^*	Human herpesvirus 8	Pathogen	120 genes	PCR products on nylon	Virus gene expression during latent and lytic replication	\|\|
Human T-cell^†	Human immuno-deficiency virus type 1	Host	1,500 genes	PCR products on glass slides	Host gene expression during 72 hours of virus infection	[7]
Normal human keratinocytes	Human papillomavirus type 31	Host	7,075 genes	PCR products on glass slides	Host gene expression following transfection of the viral genome	[8]
Human foreskin fibroblasts	Human cytomegalovirus	Host	6,600 genes	Affymetrix microarrays	Host gene expression during 24 hours of virus infection	[6]
Human colorectal^‡ and colon^§ epithelial cells	Salmonella dublin	Host	4,300 genes	PCR products on nylon	Host gene expression during 20 hours of bacterial infection	[10]
Human monocytes^¶	Listeria monocytogenes	Host	6,800 genes, 18,367 genes, 588 genes	Affymetrix microarrays, PCR products on nylon	Host gene expression during 2 hours of bacterial infection	[9]

^*Primary effusion lymphoma cell line BC-3; ^†T-cell lymphoma cell line CEMCCRF; ^‡HT-29 cells; ^§T84 cells; ^¶THP- I cells. ^||R.G. Jenner, et al., unpublished observations.

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