Figure 2

Structure of WASP proteins. WASP and N-WASP are highly homologous and contain several domains known to interact with specific proteins. These include the WH1 domain, which may bind to PIP²; a calmodulin-binding IQ domain (only in N-WASP); a Cdc42/Rac-interacting binding (CRIB) domain; a polyproline-rich region that can interact with SH3 domains in a variety of proteins and with profilin; a WH2 domain which interacts with actin (there are two WH2 domains in N-WASP); and an acidic carboxy-terminal domain which interacts with the Arp2/3 complex.