Skip to main content

Table 2 Conservation of Tlr4 among six mammalian species, calculated according to region

From: Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)

  Human Chimp Baboon Rat Mouse Hamster
Extracellular domain       
   Human 100%      
   Chimp    99.6% 100%     
   Baboon    91.5%    91.5% 100%    
   Rat    61.3%    60.7%    59.4% 100%   
   Mouse    61.9%    62.0%    60.1%    82.9% 100%  
   Hamster    64.3%    64.2%    62.5%    73.8%    74.8% 100%
Proximal cytoplasmic domain       
   Human 100%      
   Chimp    99.4% 100%     
   Baboon    99.4%    98.7% 100%    
   Rat    91.7%    91.0%    91.0% 100%   
   Mouse    90.4%    89.7%    89.7%    98.1% 100%  
   Hamster    91.7%    91.0%    91.0%    97.4%    95.5% 100%
Transmembrane domain       
   Human 100%      
   Chimp 100% 100%     
   Baboon    97.1%    97.1% 100%    
   Rat    67.7%    67.7%    67.7% 100%   
   Mouse    70.6%    70.6%    70.6%    91.2% 100%  
   Hamster    73.5%    73.5%    73.5%    79.4%    79.4% 100%
Distal cytoplasmic domain       
   Human 100%      
   Chimp 100% 100%     
   Baboon    50%    50% 100%    
   Rat    38.1%    38.1%    ns 100%   
   Mouse    26.3%    26.3%    ns    63.2% 100%  
   Hamster    40.9%    40.9%    ns    40.96%    45.5% 100%
  1. With respect to the human sequence, the extracellular domain is amino acids 1-624; transmembrane domain, amino acids 625-658; proximal cytoplasmic domain, amino acids 659-618; distal cytoplasmic domain, amino acids 619-638. Homology estimates were generated by multiplex FASTA comparison; ns, not significant.