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Table 1 Polymorphisms of Tlr4 in mice

From: Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)

  Genomic nucleotide Exon/intron Altered Affected receptor  
Mouse strain* affected affected amino acid domain Conserved?
10 26,400 A → G Exon 1 - -  
4, 8, 20, 21, 22 37,685: (T)10 Intron 2 - -  
34, 35 37,685: (T)12 Intron 2 - -  
23 37,754 G → A Exon 3 D94N Ecto Yes
4, 8, 10, 20, 21, 34, 35 38,101 G → A Exon 3 M2091 Ecto Yes
21 38,130 A → G Exon 3 D219G Ecto No
4, 8, 21 38,234 G → A Exon 3 V2541 Ecto Yes
10 38,584 A → G Exon 3 - -  
21 38,742 A → T Exon 3 Q423L Ecto Yes
10 38,794 G → A Exon 3 - -  
10 38,903 G → T Exon 3 A477S Ecto Yes
18 39,020 A → G Exon 3 T516A Ecto Yes
4, 8, 10, 20, 21, 22, 34, 35 39,199 C → T Exon 3 - -  
4, 8, 10, 20, 21, 34, 35 39,253 A → C Exon 3 E593D Ecto Yes
23 39,273 A → T Exon 3 N6001 Ecto No
10 39,294 C → T Exon 3 A607V Ecto Yes
10 39,383 G → A Exon 3 V6371 TM No
10 39,544 G → A Exon 3 - -  
19 39,604 T → C Exon 3 - -  
4, 8, 20, 21, 34, 35 39,631 C → T Exon 3 - -  
4, 8, 20, 21, 34, 35 39,756 G → A Exon 3 R761H Cyto Yes
10 39,907 T → G Exon 3 N811K Cyto Yes
  1. *Strains are as follows: I, NZO/HILt; 2, SI/Col; 3, DBA/IJ; 4, A/J; 5, EL/Suz; 6, CBA/J; 7, AKR/J; 8, BALB/cJ; 9, DDY/JcI; 10, P/J; I I, MRL/MPJ; 12, SJL/J; 13, NOD/LtJ; 14, 129/J; 15, FL/IRe; 16, MA/MyJ; 17, SWR/J; 18, LP/J; 19, PRO/IReJ; 20, SODI/Ei; 21, SEA/GnJ; 22, SM/J; 23, KK/HIJ; 24, ST/bJ; 25, WB/Re; 26, YBR/Ei; 27, FVB/NJ; 28, PL/J; 29, LT/ChReSv; 30, RILLS/J; 31, RF/J; 32, NZB/BINJ; 33, AU/SsJ; 34, NZW/LacJ; 35, VM/Dk.
  2. Exon I, 26041-26424; Exon 2, 32397-32563; Exon 3, 37732-41297. ATG at 26335; TGA at 39982. Ecto, extracellular domain; Cyto, cytoplasmic domain;
  3. TM, transmembrane domain.
  4. Yes implies one or two forms; No implies three to five forms among the six mammalian species examined.