Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)

Table 1 Polymorphisms of Tlr4 in mice

	Genomic nucleotide	Exon/intron	Altered	Affected receptor
Mouse strain*	affected	affected	amino acid	domain^†	Conserved?^‡
10	26,400 A → G	Exon 1	-	-
4, 8, 20, 21, 22	37,685: (T)₁₀	Intron 2	-	-
34, 35	37,685: (T)₁₂	Intron 2	-	-
23	37,754 G → A	Exon 3	D94N	Ecto	Yes
4, 8, 10, 20, 21, 34, 35	38,101 G → A	Exon 3	M2091	Ecto	Yes
21	38,130 A → G	Exon 3	D219G	Ecto	No
4, 8, 21	38,234 G → A	Exon 3	V2541	Ecto	Yes
10	38,584 A → G	Exon 3	-	-
21	38,742 A → T	Exon 3	Q423L	Ecto	Yes
10	38,794 G → A	Exon 3	-	-
10	38,903 G → T	Exon 3	A477S	Ecto	Yes
18	39,020 A → G	Exon 3	T516A	Ecto	Yes
4, 8, 10, 20, 21, 22, 34, 35	39,199 C → T	Exon 3	-	-
4, 8, 10, 20, 21, 34, 35	39,253 A → C	Exon 3	E593D	Ecto	Yes
23	39,273 A → T	Exon 3	N6001	Ecto	No
10	39,294 C → T	Exon 3	A607V	Ecto	Yes
10	39,383 G → A	Exon 3	V6371	TM	No
10	39,544 G → A	Exon 3	-	-
19	39,604 T → C	Exon 3	-	-
4, 8, 20, 21, 34, 35	39,631 C → T	Exon 3	-	-
4, 8, 20, 21, 34, 35	39,756 G → A	Exon 3	R761H	Cyto	Yes
10	39,907 T → G	Exon 3	N811K	Cyto	Yes

*Strains are as follows: I, NZO/HILt; 2, SI/Col; 3, DBA/IJ; 4, A/J; 5, EL/Suz; 6, CBA/J; 7, AKR/J; 8, BALB/cJ; 9, DDY/JcI; 10, P/J; I I, MRL/MPJ; 12, SJL/J; 13, NOD/LtJ; 14, 129/J; 15, FL/IRe; 16, MA/MyJ; 17, SWR/J; 18, LP/J; 19, PRO/IReJ; 20, SODI/Ei; 21, SEA/GnJ; 22, SM/J; 23, KK/HIJ; 24, ST/bJ; 25, WB/Re; 26, YBR/Ei; 27, FVB/NJ; 28, PL/J; 29, LT/ChReSv; 30, RILLS/J; 31, RF/J; 32, NZB/BINJ; 33, AU/SsJ; 34, NZW/LacJ; 35, VM/Dk.
^†Exon I, 26041-26424; Exon 2, 32397-32563; Exon 3, 37732-41297. ATG at 26335; TGA at 39982. Ecto, extracellular domain; Cyto, cytoplasmic domain;
TM, transmembrane domain.
^‡ Yes implies one or two forms; No implies three to five forms among the six mammalian species examined.

ISSN: 1474-760X