Fig. 5
From: Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
Large hypomethylated regions in colorectal metastasis. a HMRs derived from the metastatic colorectal cancer sample ranked by genomic size. Large HMRs are indicated (red dots). b–d DNA methylation profile of the HMRs spanning CTNNB1 (b), SLC12A2 (c) and AXIN2 (d) in the normal (yellow) and metastatic (red) samples. Smoothed (colored line), raw (gray bars) CpG methylation levels and hypomethylated regions (colored bars) are indicated. e, f Validation of the large HMRs associated with CTNNB1 (e) and AXIN2 (f) using the HumanMethylation450 BeadChip. Displayed are average CpG methylation levels of CTNNB1 and AXIN2 for 18 normal colon mucosa and 24 colorectal metastasis samples. Significant differences were assessed using Student’s t-test