Fig. 6

Multi-omics analysis of adult and fetal colon tissues revealed distinct variations between adults and fetuses as well as across omics. A UMAP of cell types present in the scATAC-Seq of the adult colon. Colors represent cell types. B Top enriched motif sequences in cell types of the adult colon scATAC-Seq data. C,D Spatial transcriptomic profiles of adult colon sample 1 (C) and sample 2 (D). The top TFs were selected, and their spatial expressions were mapped onto the slide images. E,F Top receptor-ligand interactions between cell type classes in colon 1 (E) and colon 2 (F) of the spatial transcriptomics data. Color blocks on the outer circle represent the cell type class, and the color in the inner circle represents the receptor (blue) and ligand (red). Arrows indicate the direction of receptor-ligand interactions. G,H Top receptor-ligand interactions between cell type classes in the adult colon (G) and fetal colon (H) of the scRNA-seq data. Color blocks on the outer circle represent the cell type class, and the color in the inner circle represents the receptor (blue) and ligand (red). Arrows indicate the direction of receptor-ligand interactions