Fig. 4

GRN and TFA inference in PBMC. A UMAP projection of predicted TFA for each annotated PBMC cell type. B Predicted IRF2 TFA demonstrates high activity in NK and CD8 T cells. C GRN between IRF TFs and their targets. Pink edges indicate literature support for interaction. D Heat-map dot-plot depicting TFA of selected immune TFs across annotated PBMC cell types. E Heat-map dot-plot indicates ten most highly active TFs for each PBMC cell type. F Violin plot demonstrates corresponding distribution of TFA profiles for ten most highly active TFs