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Fig. 5 | Genome Biology

Fig. 5

From: Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes

Fig. 5

Clusters of TRB clones that are specific to rheumatoid arthritis and associated with HLA class II alleles. Clusters of TRB clones that are associated with HLA class II alleles and specifically enriched in the immune repertoire of rheumatoid arthritis patients compared to a naive repertoire of CD4 + (left side) and CD8 + T cells (right side). The most representative amino acid motif of those clones that are clustered together is used for the cluster naming. Clusters of TRB clones are sorted according to the Levenshtein distance among amino acid motifs. The number of unique clones belonging to each cluster and the number of patients having the indicated cluster are used for the cluster characterization. Each motif-allele pair is colored in accordance with the statistical significance of the motif enrichment in rheumatoid arthritis. The size of each association is proportional to the statistical significance of the genetic association between the indicated HLA allele and amino acid motif. The name of each amino acid motif is based on the nomenclature used by the GLIPH algorithm. Abbreviations: N, sample size, P, p-value; RA, rheumatoid arthritis

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Genome Biology

ISSN: 1474-760X

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