Fig. 9
From: Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
A proposed model showing the role of BP1 phase separation in maintaining the transcriptional repression of DON mycotoxin biosynthesis genes. Under normal growth condition, H3K27me3 reader BP1 undergoes LLPS to form dynamic phase-separated liquid condensates in the nucleus. The condensates recruit and concentrate PRC2 protein complex (Kmt6-Suz12-Eed) to effectively regulate transcriptional repression of H3K27me3 binding genes, such as DON mycotoxin biosynthesis TRI genes, leading lower DON production