Fig. 6

Analysis of MG pairs from MGPs predicted using Human1 for the 16 AML samples and the 20 RCC samples. The same analysis was performed by using Human1 as a template model for the data presented in Fig. 3. a Number of MGPs predicted for the seven mutated genes from the 16 AML samples. As in Fig. 3a, the samples having IDH1 or IDH2 mutation were also considered together, presented as “IDH.” b Classification of the detected peaks from relative quantification of metabolites from the 17 AML samples. c AUC values of target metabolites from the final seven MGPs. The black dashed line indicates the AUC value of 0.7. d AUC values for target metabolites from the final seven MGPs (red dots) and 61 metabolites from the AML metabolome data; these 61 metabolites include those not predicted as a target metabolite for MGPs and are paired with each of the presented target genes (box plots). These 61 metabolites correspond to the peaks in the metabolome data that are annotated, and also present in the GEMs in b. e–h Same types of data presented in a–d for the 21 RCC samples. In e, MGPs were predicted for the six mutated genes from the 20 RCC samples. As in Fig. 3e, the samples having NOTCH1 or NOTCH2 mutation were considered together as “NOTCH,” and the samples having ERBB2, ERBB3, or ERBB4 mutation were considered together as “ERBB.” In h, AUC values for target metabolites from the final 14 MGPs (red dots) and 111 metabolites from the RCC metabolome data are presented. These 111 metabolites include those not predicted as a target metabolite for MGPs and are paired with each of the presented target genes (box plots)