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Fig. 4 | Genome Biology

Fig. 4

From: Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data

Fig. 4

Overview of the predicted MGPs across 18 cancer types. a Number of samples and mutated genes considered in this study, and the number of predicted MGPs for each cancer type. b Percentages of submetabolisms (on the basis of KEGG pathways) where MGPs were predicted for each cancer type. Colors in bar graphs indicate submetabolisms that are presented in d. c, d Ten target genes associated with the greatest number of MGPs where c the number of cancer types and d the number of submetabolisms are presented for each target gene. e Distribution of target metabolites associated with the MGPs predicted for the 18 cancer types across the genome-scale human metabolic pathways. Target metabolites and submetabolisms related to target pathways in the MGPs are presented in the metabolic map without target genes. Frequency, shown with different colors between blue and red, refers to the number of cancer types where a target metabolite appeared

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Genome Biology

ISSN: 1474-760X

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