Fig. 3
From: A comparison of methods for detecting DNA methylation from long-read sequencing of human genomes
Comparison of CpG methylation detection by method. CpG methylation rates (ranging from 0 to 1) averaged across individuals yield the expected bimodal distribution seen in oxBS data for A oxBS, Guppy R9.4, and R10.4 and B oxBS, PacBio, and Nanopore. The units on y-axis are millions (M). C CpG methylation rates averaged in 50-bp bins relative to transcription start sites (TSSs) of genes expressed in whole blood. D Number of CpGs called by each method. For Nanopolish, we count all CpGs within a CpG unit. Note that the y-axis is limited from 24.5 to 27.7 M (millions). The center line (solid black) shown in each box represents the median; the box limits represent the upper and lower quartile; the whiskers represent the 1.5 × interquartile range