Fig. 6

Perturbation of ligand/receptor reveals cooperative behavior during cancer evolution. A Results from evolutionary path analysis of mutated ligand-receptor interaction. Only the q value <  = 0.1 was shown. B Result from clonal selection analysis of mutated ligand-receptor interaction. “metastasis” versus “primary” (left panel) and “progression disease (PD),” “partial response (PR),” and “stable disease (SD)” in lung cancer (right panel). Only the q value <  = 0.1 was shown. A, B The bar indicates the mean spearman correlation coefficient from each group. The standard error is shown as an error bar. C Kaplan–Meier curve of non-small-cell lung cancer patients in TCGA data with each category. Jaccard index of mutation was obtained between mutation profiles in each sample with mutated receptors interacting with a given cell type