Fig. 5
HIm and N2p chromosomes show altered large-scale folding. A Matrices of mean pairwise distances in µm for subpopulations of chromosome conformations for crosses as determined by unsupervised clustering. Traces from both crosses were pooled and analyzed together as described in Figure 2H. Missing data are marked in gray. Axis numbering represents positions across the chromosome as shown in Figure 1C. B Distribution of traces within clusters from A shows all crossed strains have similar cluster proportions, except for cluster 5 which is enriched in HIm and N2p traces. Chi-square statistic was 138.209, p-value= 0 and Cramér’s V=0.120. C Standardized residual for chi-square testing to reveal conformations that are enriched (red) or deficient (green) relative to expectation