Fig. 5
From: SHARE-Topic: Bayesian interpretable modeling of single-cell multi-omic data
a Analysis of the activity of the enhancer in gene FOXP1. According to the SCREEN database, the regions are intersected to distal enhancer-like sites and sometimes also CTCF-bound sites. The SHARE-Topic score is scattered on the open chromatin regions (annotated as enhancers) from the B-lymphoma dataset. The enhancer regions shown are located within a window of \(10^5\) within and around FOXP1. The curve is fitted by taking the average of the SHARE-Topic score on intervals of length \(10^3\) nucleotide. According to the SHARE-Topic score, the enhancers at the starting site of FOXP1 are shown to have a higher contribution to the gene activity. b SHARE-Topic score for regions at distance 105 from two genes (CD35, XRCC5) in the B-lymphoma dataset. The regions are annotated using the SCREEN database as promoter-like sites (PLS), CTCF-bound sites, and proximal/distal enhancer-like sites (p/dELS)