Fig. 1
From: SHARE-Topic: Bayesian interpretable modeling of single-cell multi-omic data
Workflow of SHARE-Topic: the scATAC-seq binary data and the expression matrix of the scRNA-seq data are fed to SHARE-Topic. SHARE-Topic extracts latent representation in topic space for each cell, gene, and region in the data. The latent representation of the cells is used to visualize the heterogeneity in cell types using Umap. The latent representations of genes and regions are used to extract biological interactions between genes and regions that shape the regulatory mechanisms in the cells