Fig. 1
From: SSBlazer: a genome-wide nucleotide-resolution model for predicting single-strand break sites
Overview of our work. a The experimental and bioinformatics pipeline for constructing the datasets from two different SSB detection methods (S1 END-seq and SSiNGLe-ILM). b The computational framework and SSBlazer. c The downstream analysis of the putative genome SSB landscape. For example, gradient-based model interpretation analysis reveals that the model can capture the specific motif pattern of the putative SSB sites. The cross-species analysis provided the genome-wide SSB site landscape across various genomes. The mutation analysis profiled alterations in the SSB landscape, identifying SSB-related SNPs