Fig. 5
From: Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Spatial transcriptomics in the kidney identifies a pro-fibrotic microenvironment. A UMAP of integrated spatial datasets with neighborhood annotations PT, proximal tubule; PT_INJ, injured proximal tubule; TL, thin limb; TAL, thick ascending limb; DCT, distal convoluted tubule; CD, collecting duct; FIB_VSMC, fibroblasts and vascular smooth muscle cells; GLOM, glomeruli. B Representative spot annotation and visualization of spatial neighborhoods. C CellChat midkine secreted signaling arising from the PT_INJ neighborhood. D CellChat endothelin secreted signaling arising from the PT_INJ neighborhood. E CellChat EGF secreted signaling arising from the PT_INJ neighborhood. F Gene ontology enrichment for PT_INJ spot-specific differentially expressed genes