Fig. 3
From: Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
LOY detection by scRNA-seq. A UMAP of male and female kidney cell types PT, proximal tubule; PT_VCAM1, VCAM1 + proximal tubule; PT_PROM1, PROM1 + proximal tubule; PT_MT, mitochondrial gene proximal tubule; PEC, parietal epithelial cells; LOH, loop of Henle; DCT, distal convoluted tubule; PC, principal cells; IC, intercalated cells; PODO, podocytes; ENDO, endothelial cells; FIB_VSMC_MC, fibroblasts; vascular smooth muscle, and mesangial cells, LEUK—leukocytes. B RNA modality LOY density plot in 78,738 male cells. C Median proportion LOY in male kidney cell types. D Log-fold-change gene expression for LOY vs. XY in male kidney cell types. E Proportion LOY in Control or AKI vs CKD male samples. F GLMM for LOY in male kidney cell types adjusted for CKD