Fig. 3

Hormone mediated changes in GATA3 chromatin binding in ER-positive breast cancer cells. A Volcano plot reporting the FDR adjusted p-value and the log2FC of GATA3 chromatin binding events in T-47D breast cancer cells treated with E2 vs Veh. Thresholds are set as in Fig. 2. B Venn diagram showing the overlap of significantly enriched (FDR < 0.05) GATA3 binding sites with E2 or DHT. C Volcano plot reporting the FDR adjusted p-value and the log₂FC of GATA3 chromatin binding events with simultaneous hormone treatment (E2 + DHT) vs DHT alone. For visualization of differential binding patterns, the threshold for gain or loss in volcano plots is shown as in Fig. 2. D Differential ER binding (from [8], FDR < 0.05, no fold-change threshold) at AR and GATA3 shared sites