Fig. 2
From: txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility
Cell type identification and marker assessment in human cortex sample. a UMAP projection of human cortex nuclei (n = 28,663). Nuclei are colored by their predicted cell type. b Heatmap of z-scored average gene activity score per cluster for canonical markers from Brain Map datasets. Astro: astrocytes; Endo: endothelial cells; ExN: excitatory neurons; GABA: GABAergic; Glu: Glutamatergic; iN: inhibitory neurons; Micro: microglia; Micro.PVM: microglia and perivascular macrophages; NonN: Non-neuronal; Oligo: oligodendrocytes; OPC: oligodendrocyte progenitor cells. c De novo determination of TF marker genes through chromatin accessibility-derived gene activity (left) and TF motif usage (right). Z-scored average gene activity score and TF motif usage per cluster are plotted for the top 5 markers within each cluster. TF markers are ranked by AUC reported from one vs. rest Wilcoxon rank sum test. TF motifs are shown on the right as SeqLogos alongside heatmap rows