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Table 2 Polygenic risk score results in the UK Biobank

From: Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Phenotype

PRS R2 a

Full model R2 b

PRS P

Number SNPs in PRS

I (10F/12 M)

 Atrial fibrillation diagnosis

0.000215

0.030

3E − 25

4133

 BMI

8E − 05

0.017

3E − 10

4133

 Extreme BMI

2E − 05

0.003

0.0006

4133

 T2D all

2E − 05

0.032

0.001

4133

IV (a-size)

 Atrial fibrillation diagnosis

3E − 05

0.030

0.0003

383

V (b-timing)

 BMI

2E − 05

0.017

0.0005

350

VI (c-intensity)

 BMI

6E − 05

0.017

5E − 08

457

 Atrial fibrillation diagnosis

2E − 05

0.030

0.0006

457

  1. aProportion of variance explained by the polygenic risk score (PRS)
  2. bProportion of variance explained by the full model including covariates (array, sex, age, PC1, PC2, PC3, PC4, PC5, PC6) and PRS
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Genome Biology

ISSN: 1474-760X

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