Fig. 5

Performance on the regulation saturation expression challenge. The two left columns show performance in predicting increased (left) and decreased (right) expression in a set of enhancers (purple points represent variants that significantly change expression). The right pair of columns show equivalent results for promoters. The scatter plots (A) show strong performance in identifying decreases in expression (purple points), but weaker results for expression increases. Performance on promoters is stronger than on enhancers. Overlap of changed and non-changed experimental expression points suggests that experimental uncertainty reduces the apparent performance of the computational methods. Panel B shows correlation coefficients for selected methods. Panel C shows ROC curves for predicting under and overexpression. Panel D shows local \({{\text{lr}}}^{+}\), where the solid lines are smoothed fits to the data