Fig. 4

Human lung cellular landscape in response to SARS-CoV-2 infection. a Clustering of the human transcriptome data across COVID-19 and control sections reveals 6 distinct clusters with SARS-CoV-2⁺ spots distributed throughout the clusters. b Differential genes per cluster across COVID-19 and control sections. c Spatial distribution of the clusters on COVID-19 and control sections. Scale bars are 500 µm. d, e Spatial distribution of genes upregulated in COVID-19 sections, COL3A1 (d) and LYZ (e). Scale bars are 500 µm. Differential expression analysis used the Wilcoxon rank sum test and “bimod” Likelihood-ratio tests, p-value < 0.05