Fig. 8

Motifs predictive of chromatin accessibility. A–C Motifs identified by TF-MoDISco are shown at the bottom of each panel while known motifs from the JASPAR insect collection are shown at the top of each panel. A A motif corresponding to Trl was predictive of open chromatin in both tissues. B The cad motif was predictive of closed chromatin in both tissues. C The ttk motif was predictive of closed chromatin in the testis. D–E Motifs predictive of inaccessibility (D) and accessibility (E) that do not significantly align with motifs in the JASPAR database. F The effect of inserting TF-MoDISco identified consensus motifs predictive of accessibility and inaccessibility into the center of non-peak and peak examples, respectively. The five motifs with the largest median impact on model output in each condition are shown