Fig. 5

Chromatin accessibility can be accurately predicted from short contiguous subsequences. A Short subsequences identified from in silico mutagenesis are predictive of chromatin accessibility. For each example, the short subsequence corresponding to the window with the largest moving average importance was inserted into a constant genomic background. Ten sequences with low baseline model outputs were randomly selected, and AUROCs were calculated for model performance. B Deletion of windows with the highest importance in each example did not substantially diminish model performance for small windows. Deletions were performed by substituting the native subsequence with a random sequence, and AUROCs were calculated for model performance