Fig. 2

The sequence determinants of chromatin accessibility are highly conserved. A Venn diagram of the peak conservation across species. We combined the sets of peaks from the head and testis into a single set per species and used a reference-free multi-context approach to identify the orthologous regions for each peak in the other two species (see the “Methods” section). Between two-thirds and three-fourths of peaks identified in each species are conserved. B, C Each model (trained in a given species) was tested in the other two species. The AUROC of each model tested in a non-native species was divided by the AUROC of the native model. D, E The models can predict chromatin accessibility in the head of D. suzukii and the brain of Aedes aegypti