Table 2 Enrichment analysis of the noncoding regions of genes under positive selection in humans
Term | Input (Background) | Corrected p value |
|---|---|---|
Pathway (top 10 terms) | ||
 Metabolism | 36 (2075) | 6.23E − 03 |
 Porphyrin and chlorophyll metabolism | 5 (42) | 6.23E − 03 |
 Neuronal system | 13 (402) | 6.60E − 03 |
 Retrograde endocannabinoid signaling | 8 (148) | 6.60E − 03 |
 EGF receptor signaling pathway | 7 (114) | 7.40E − 03 |
 Signaling by interleukins | 16 (619) | 9.10E − 03 |
 Diseases of signal transduction | 12 (374) | 9.63E − 03 |
 Cell cycle | 16 (629) | 1.01E − 02 |
 Oocyte meiosis | 7 (128) | 1.17E − 02 |
 Negative regulation of the PI3K/AKT network | 6 (96) | 1.49E − 02 |
Disease (top 10 terms) | ||
 Obesity-related traits | 21 (691) | 4.41E − 04 |
 Schizophrenia | 9 (181) | 5.76E − 03 |
 Height | 12 (395) | 1.31E − 02 |
 Immune response to smallpox (secreted IL-2) | 3 (13) | 1.69E − 02 |
 Myocardial infarction (early onset) | 3 (14) | 1.92E − 02 |
 Metabolite levels (HVA/MHPG ratio) | 3 (17) | 2.61E − 02 |
 Bone mineral density (hip) | 3 (18) | 2.87E − 02 |
 Alzheimer’s disease (cognitive decline) | 4 (46) | 3.00E − 02 |
 Renal function-related traits (BUN) | 3 (19) | 3.00E − 02 |
 Bone mineral density | 5 (85) | 3.16E − 02 |
GO (top 20 terms with < 500 background genes) | ||
 Learning or memory | 6 (60) | 5.45E − 03 |
 Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 5 (35) | 5.45E − 03 |
 Synapse | 14 (420) | 5.45E − 03 |
 Postsynapse | 7 (93) | 5.45E − 03 |
 Regulation of neuron apoptotic process | 4 (17) | 5.54E − 03 |
 Regulation of translation | 6 (63) | 5.54E − 03 |
 Myoblast differentiation | 4 (18) | 5.72E − 03 |
 Transcription factor binding | 12 (325) | 5.72E − 03 |
 Flavone metabolic process | 3 (5) | 5.72E − 03 |
 Neuron projection | 12 (336) | 6.23E − 03 |
 GABA-ergic synapse | 6 (70) | 6.23E − 03 |
 Flavonoid glucuronidation | 3 (6) | 6.23E − 03 |
 Brain morphogenesis | 4 (21) | 6.60E − 03 |
 Coumarin metabolic process | 3 (7) | 7.40E − 03 |
 Glucuronosyltransferase activity | 4 (23) | 7.40E − 03 |
 Neuron projection development | 7 (116) | 7.92E − 03 |
 Dendrite | 13 (420) | 7.92E − 03 |
 Xenobiotic glucuronidation | 3 (8) | 8.26E − 03 |
 Positive regulation of catalytic activity | 6 (82) | 8.82E − 03 |
 Gamma-aminobutyric acid signaling pathway | 4 (27) | 1.01E − 02 |