Fig. 6

The enriched functions or pathways upon noncoding variants with strong geographic differentiation. The height of the yellow bar indicates the number of genes assigned to noncoding variants that are strongly geographically differentiated and significantly change the chromatin profile. To estimate the number of genes expected to observe for each function or pathway term, the gene fraction in the P. falciparum genome presenting the specific functional term is multiplied by the number of assigned genes to geographic differential variants exhibiting the high chromatin effects (hypergeometric test, FDR-corrected p-value < 0.1, check Additional file 9: Table S8 for full list)