Fig. 5

Noncoding variants with high levels of geographic differentiation tend to alter their surrounding chromatin profiles. A Noncoding variants strongly differentiated at the global level are closer to their neighboring genes. We used global Fst > 0.1 to identify variants with high levels of geographic differentiation. ***Wilcoxon test compared with the remaining noncoding variants, p < 2.2e − 16. B Noncoding variants that acquired high geographic differentiation (Fst > 0.1) are predicted to bring in significant epigenetic changes at their ± 100-bp surrounding regions