Fig. 8

Isoform-specific antagonistic dominant eQTLs. Manhattan plots of Foxj2 (a–c) and Atp5g2 (g–i), based on their overall gene expression levels in HS rat amygdala, and showing no genome-wide significant eQTLs; a Foxj2 (g): Atp5g2, with their associated isoforms’ expression levels b Foxj2A, c Foxj2B, h Atp5g2A, i Atp5g2B, and showing isoform-specific cis-eQTLs. Plot layouts are as for Fig. 3, showing Manhattan plots color-coded by dominance classification, regional QTL plots, and phenotype-genotype distribution at peak SNPs. The isoform structures for Foxj2, Atp5g2 from UCSC Genome Browser are inset. d–f Scatter plots of the correlations of expression levels between Foxj2A vs. Foxj2 (d), Foxj2B vs. Foxj2 (e), and Foxj2A vs. Foxj2B (f). j–l Scatter plots of the correlations of expression levels between Atp5g2A vs. Atp5g2 (j), Atp5g2B vs. Atp5g2 (k), and Atp5g2A vs. Atp5g2B (l). Within each scatter plot, one dot represents one sample and the dot colors indicate the genotypes at the corresponding peak SNPs