Fig. 5

Trans-acting enrichment among dominant isoform-level eQTLs in HS rats. a–h eQTL locations of isoform-level eQTLs, filtered by dominance type. Each dot represents an eQTL significant at suggestive level (i.e., one false positive eQTL expected per isoform). x-axis: eQTL position, y-axis: physical gene location. First row a–d amygdala; Second row (e, h): heart. The four columns represent dominance types (blue: additive A, sky blue: partial-dominant PD, purple: complete-dominant CD, red: over-dominant OD). i Fisher’s exact test for the enrichment of trans-acting eQTLs among dominance eQTLs based on suggestive significant threshold (upper) or whole genome significant threshold (lower). j Dominance trans-acting enrichment (left y-axis, solid lines) and the counts of significant eQTLs (right y-axis, dashed lines) under different − log₁₀(P) eQTL significance thresholds (x-axis). Enrichment is quantified by the − log₁₀(P) values of Fisher exact test between dominance (Add/Dom-eQTLs) and regulation types (cis/trans-acting) of significant eQTLs within rat amygdala (black) and heart (orange), respectively