Table 2 Summary of experimental datasets. For each dataset, we list the library description (Library); sequence length in nucleotides (L); number of unique library sequences after holding out experimentally validated variants, if needed (\(M'\)); number of experimentally validated variants (n); \(\%\) of the sequence of interest covered by individual reads (Cover); number of pre-selection reads (\(N^\text {pre}\)); and number of post-selection reads (\(N^\text {post}\)). For the dataset from Huisman et al. [17], the number of reads for each round of selection is presented on a separate row

From: MBE: model-based enrichment estimation and prediction for differential sequencing data