Fig. 8

Expression and pLI scores per ChromGene annotation. Scatter plot showing gene expression (RPKM) on the x-axis and the proportion of high-pLI genes (pLI ≥ 0.9) on the y-axis. Each point corresponds to genes assigned to a specific ChromGene annotation in a single cell type. Points are colored by their ChromGene annotation. The dashed line corresponds to the overall proportion of genes with high pLI. Gray curves represent the proportion of high-pLI genes as a function of expression, one per cell type. The dotted black line is the proportion of high-pLI genes, averaged across cell types, as a function of expression (“Methods”). The figure shows that although there is a positive association between the two measures, ChromGene captures information beyond expression. For example, “trans_enh” and “trans_cons” have similar expression levels, but substantially different proportions of high-pLI genes