Fig. 1

We test the null hypothesis that the probability that a gene is present are equal for tongue and plaque-associated Saccharibacteria genomes. The top 3 panels show core genes for which our proposed method resulted in greater p-values than existing methods, and the lower 3 panels show accessory genes for which our proposed method resulted in smaller p-values than existing methods. Our method reduced p-values when differences in detection cannot be attributed to genome quality factors (here, coverage), and increased p-values in situations when non-detection may be conflated with lower quality genomes. Points have been jittered vertically to separate observations