Fig. 1
From: COLLAGENE enables privacy-aware federated and collaborative genomic data analysis
Illustration of the collaborative analysis framework that COLLAGENE implements. Three sites are shown as an example. The sites (rounded rectangles), which host their local datasets, initiate key request from KeyMaker. After keys are generated, each site download and decrypt their key shares. Sites also have a common encryption (i.e., public key, green). Next, sites setup a shared space on an FTP server or on the cloud, e.g., AWS S3 bucket. According to the agreed protocol, each sites process their local data using COLLAGENE’s tools and upload encrypted intermediate results to the shared space. Sites download intermediate results from other sites and process these for the next iteration. After all the iterative analysis steps are complete, the sites perform collective decryption as specified by the agreed protocol. Note that KeyMaker only participates in the key generation and does not (and should not) take part in data analysis protocol