Table 2 Univariate and multivariate analyses for clinical characteristics of EFS and OS in pediatric AML patients

Age > 10

1.24 (0.826–1.86)

0.299

1.41 (0.853–2.34)

0.179

BM blast > 70%

1.36 (0.822–2.25)

0.231

1.25 (0.675–2.3)

0.482

CD69⁺ HSC-like% (high vs low)

1.51 (0.984–2.33)

0.059^*

2.02 (1.22–3.36)

0.007^***

1.05 (0.565–1.95)

0.880

1.96 (0.891–4.3)

0.095^*

LSC score (high vs low)

2.02 (1.34–3.06)

0.001^***

1.97 (1.17–3.3)

0.010^**

2.39 (1.35–4.23)

0.003^***

2.12 (0.993–4.53)

0.052^*

WBC > 30

1.20 (0.781–1.86)

0.400

1.08 (0.632–1.83)

0.787

Gender (male vs female)

0.894 (0.596–1.34)

0.589

0.85 (0.516–1.4)

0.522

Cytogenetic inv(16)

0.811 (0.441–1.49)

0.502

0.481 (0.192–1.2)

0.118

Cytogenetic MLL

1.34 (0.804–2.22)

0.263

1.26 (0.667–2.38)

0.475

Cytogenetic Normal

0.661 (0.408–1.07)

0.093^*

0.766 (0.425–1.38)

0.377

Cytogenetic Other

2.80 (1.75–4.47)

0.000^***

2.45 (1.4–4.28)

0.002^***

Cytogenetic t(8;21)

0.495 (0.256–0.957)

0.037^*

0.629 (0.285–1.39)

0.251

Risk group High

1.37 (0.746–2.52)

0.310

1.24 (0.561–2.73)

0.597

Risk group Standard

2.55 (1.67–3.89)

0.000^***

2.36 (1.39–4.01)

0.001^***

1.34 (0.5–3.6)

0.560

1.30 (0.397–4.23)

0.667

Risk group Low

0.337 (0.214–0.531)

0.000^***

0.369 (0.207–0.658)

0.001^***

0.694 (0.244–1.98)

0.494

0.681 (0.181–2.56)

0.570

FLT3-ITD

1.63 (0.972–2.72)

0.064^*

1.23 (0.622–2.41)

0.556

FLT3-ITD AR high

1.53 (0.795–2.95)

0.203

1.28 (0.552–2.98)

0.564

FLT3-ITD AR low

1.60 (0.774–3.3)

0.205

1.11 (0.403–3.06)

0.840

FLT3-PM

1.31 (0.68–2.53)

0.418

0.794 (0.318–1.98)

0.620

CEBPA mutation

0.259 (0.0819–0.818)

0.021^**

0.481 (0.151–1.54)

0.217

NPM1 mutation

0.30 (0.11–0.819)

0.019^**

0.255 (0.0622–1.04)

0.057^*

RUNX1 mutation

0.963 (0.237–3.91)

0.958

1.51 (0.37–6.21)

0.564

WT1 mutation

1.21 (0.646–2.27)

0.549

1.16 (0.55–2.43)

0.702

Anti-CD33 treatment

0.891 (0.564–1.41)

0.620

1.23 (0.679–2.23)

0.495

MRD at end of course 1

2.49 (1.56–3.97)

0.000^***

2.38 (1.31–4.3)

0.004^***

1.71 (0.956–3.05)

0.071^*

1.51 (0.7–3.26)

0.293

MRD at end of course 2

3.41 (1.93–6.01)

0.000^***

1.69 (0.8–3.58)

0.168

SCT in first CR

0.326 (0.132–0.808)

0.016^**

0.314 (0.0979–1.01)

0.052^*

0.366 (0.136–0.983)

0.046^**

0.367 (0.103–1.3)

0.121