Fig. 7

BamQuery: an online tool to facilitate TAs prioritization. a, b Average RNA expression of hematopoietic-specific (a) and epithelial-specific (b) MAPs in mTECs (n = 11), non-hematolymphoid GTEx tissues (n = 2389), DCs (n = 19), and hematolymphoid GTEx tissues (n = 196). Wilcoxon rank-sum test two-sided was used for comparisons (****p < 0.0001). c Average RNA expression of non-mutated human immunogenic (n = 1180) and non-immunogenic (n = 4917) MAPs in mTECs (n = 11) and DCs (n = 19). Mann–Whitney U test was used for comparisons (****p < 0.0001). d, e Average mTECs + DCs RNA expression of a random selection of MAPs from the HLA Ligand Atlas (n = 8621, 10% of the Atlas) as a function of the number of the HLA Ligand Atlas tissues presenting them (d) or as a function of the numbe/r of GTEx tissues in which the MAPs are expressed above an average of 8.55 RPHM (e). The average expression was correlated (Spearman) with the number of tissues. Error bar, SEM. f Spearman’s correlation between the number of expressed genomic locations and the average expression in mTECs and DCs of the same MAPs used in (d). The red line is a linear regression (distorted by the log transformation of the x-axis)