Fig. 6

Indels have varying impact in secondary structure, disease, and evolution. A The distribution of fitness effects of indels of varying length on surface expression of Kir2.1 divided by secondary structure is displayed as a kernel density estimate. Negative scores indicate decreased trafficking relative to WT Kir2.1. B Mean surface scores for deletions and insertions across Kir2.1’s sequence, with conserved insertion and deletion positions in the inward rectifier protein family indicated above, in red and blue as bar plots, respectively. Positions of clinically observed deletions are highlighted with arrows