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Fig. 5 | Genome Biology

Fig. 5

From: Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries

Fig. 5

Prediction performance and portability of the combined score PTRS*=PTRS+PRS vs PRS. a The prediction accuracy of the PRS (x-axis) is compared against the prediction accuracy of the PTRS (yellow) or the combined score (blue) on y-axis. The results on all of the 17 quantitative traits are shown. Each panel corresponds to one ancestry group. The p-values of the difference in prediction performance were calculated using a paired Wilcoxon signed rank test. b A summary of the difference between the prediction accuracy of PRS and the combined score (PTRS*=PRS+PTRS) is shown for each of the ancestry group. The second column shows the mean difference and the third column shows the p-values (paired Wilcoxon signed rank test comparing). c The portability of PRS (gray) and the combined score (blue) is shown for each ancestry group. The violin and box plots summarize the results from the 17 quantitative traits. Paired Wilcoxon signed rank test p-values are shown. d A summary of the difference between the portability of PRS and the combined score is shown for each of the ancestry group. The second column shows the mean difference and the third column shows the results of the paired Wilcoxon signed rank test comparing the portability of PRS versus the combined score

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