Fig. 2
From: Feature selection and dimension reduction for single-cell RNA-Seq based on a multinomial model
Example of how current approaches to normalization and transformation artificially distort differences between zero and nonzero counts. a UMI count distribution for gene ENSG00000114391 in the monocytes biological replicates negative control dataset. b Counts per million (CPM) distribution for the exact same count data. c Distribution of log2(1+CPM) values for the exact same count data