Fig. 4
From: The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy
Allele dynamics in patients are congruent with purifying selection acting on MTBC populations treated with an efficacious drug combination. a We framed the allele dynamics within patients as a Markov process where alleles are either detected (D) or not detected (ND). We estimated each transition probability by re-sampling (N = 1000) the data with replacement. We stratified the SNPs by treatment efficacy experienced by the population and translational impact. The estimated transition probabilities for all alleles separated by translational impact showing the 95% confidence interval for b all v-SNPs in efficaciously treated patients (red symbols), c all v-SNPs in non-efficaciously treated patients (dark gray symbols). NSY nonsynonymous, SYN synonymous