Fig. 4

Chromosomal locations of gene CNAs with high impact on survival signatures. a Glioblastoma multiforme (GBM). b Ovarian serous cystadenocarcinoma (OV). c Lung adenocarcinoma (LUAD). Genes are colored based on their observed mutation frequency (light red: rare, black: frequent). Heights of the peaks reflect the impact on survival signature genes. Selected gene names are displayed depending on their impact strength. Gene names of known cancer genes are underlined. Colored dots above or below genes additionally indicate the positions of previously reported cancer genes that were predicted as high-impact genes by CCTN. Only genes with significant impacts on survival signatures are shown (q<0.006 for all cohort-specific genes, one-sided Wilcoxon test comparing the gene-specific impact score obtained under CCTN against corresponding impact scores obtained under random networks of the same complexity as CCTN, see ‘Methods’ and Additional file 1: Figure S15 for details). The cohort-specific genes shown are further significantly enriched for known cancer genes (p<0.03 for each cohort, Fisher’s exact test). GBM glioblastoma multiforme, LUAD lung adenocarcinoma, OV ovarian serous cystadenocarcinoma